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Faculty Member Details

Staff Id : 05655
Name : Dr. B. RAJA
Designation : ASSOCIATE PROFESSOR
Department : BIOCHEMISTRY & BIOTECHNOLOGY
Qualification : M.Sc.,Ph.D.,
Specialization : Cardiovascular Biology
Date of Birth : 23-07-1978
Date of Joining : 01-02-2002
Present Address Contact Number E-Mail Address
26,kamarajar salai,
Tharangambadi(PO) & (TK),
Nagapattinam (DT) -609313
8940839994drrajaau@gmail.com
Research Guidance
Discipline Awarded Guidance
M.Phil./M.E./M.Sc. 12-
Ph.D. 95


Conference /Seminar / Symposia / Workshop
Conference Seminar Symposia Workshop
National International
Attended 910638
Conducted 11--3


Research Projects
Major Projects Minor Projects Total Amount (Rs.)
Completed 3-55,36,796/-
Ongoing ---
Teaching and Research Experience Industry Experience
22 Years -
Journals Conference Books Published Popular Article
National International National International
- 52 1 2 3 -

List of Publications - International
B. Raja, D.Saranya, R.Prabhu, "Role of flavonoid troxerutin on blood pressure oxidative stress and regulation of lipid metabolism.", Frontiers in bioscience, Volume 11, Number 1, Jan 2019, pp. 121-129. 10.2741/E851.
R.Ashok, B.Raja , "Antihyperlipidemic, free radical scavenging and antioxidant effects of α-pinene, in L-NAME induced hypertensive rats.", IJRAR, Volume 5, Number 4, 2018, pp. 650-662. 2018.
T.Silambarasan, J.Manivannan, B.Raja, Suvro Chatterjee, "Prevention of cardiac dysfunction, kidney fibrosis and lipid metabolic alterations in L-NAME hypertensive rats by sinapic acid Role of HMG-CoA reductase.", European Journal of Pharmacology, Volume 15, Number 777, Apr 2016, pp. 113-123. 10.1016/j.ejphar.2016.03.004.
T Rajeshwari, B Raja , "D-carvone, a Monoterpene Reverses Alterations in Heart Rate, Nitric Oxide, Aortic Lipids and Enzymatic Antioxidant Status in Nitric Oxide Deficient Hypertensive Rats.", International Letters of Natural Sciences , Volume 5, Number 1, 2015, pp. 19-31. 10.18052.
T Rajeshwari, B Raja , "Antioxidant and Free radical Scavenging Effect of D-carvone in Hypertensive Rats. In Vivo and In Vitro study.", International Letters of Natural Sciences , Volume 35, Number 1, 2015, pp. 6-12. 10.18052.
T Silambarasan, J Manivannan, MK Priya, N Suganya, B Raja, S Chatterjee , "Sinapic acid protects heart against ischemia/reperfusion injury and H9c2 cardiomyoblast cells against oxidative stress.", Biochemical and biophysical research communications , Volume 456, Number 4, 2015, pp. 853-859. 10.1016/j.bbrc.2014.12.022.
J Manivannan, J Shanthakumar, T Silambarasan, E Balamurugan, B Raja , "Diosgenin, a steroidal saponin, prevents hypertension, cardiac remodeling and oxidative stress in adenine induced chronic renal failure rats.", RSC Advances , Volume 5, Number 25, 2015, pp. 19337-19344. 10.1039/c4ra13188f.
J.Manivannan, T.Silambarasan, R.Kadarkarairaja and B.Raja, "Systems pharmacology and molecular docking strategies prioritize natural molecules as cardioprotective agents.", RSC Advances, Volume 5, Number 94, Sep 2015, pp. 77042-77055. 10.1039/C5RA10761J.
M.Saravanakumar, B.Raja, J.Manivannan, T.Silambarasan, P.Prahalathan, S.Kumar, S.K.Mishra., "Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation.", British Journal of Nutrition, Volume 14, Number 114(9), 2015, pp. 1385-1394. 10.1017/S0007114515003086. Epub 2015 Sep 8..
T Dhanalakshmi, T Rajeshwari, B Raja , "Antioxidant activity of dehydrozingerone on stz and l-name induced oxidative stress in experimental rat model.", World Journal of Pharmacy and Pharmaceutical Sciences, Volume 3, Number 9, 2014, pp. 1466-1477. 2014.
T.Silambarasan, B.Raja , "Sinapic acid attenuates high blood pressure oxidative stress and hyperlipidemia in L-NAME induced hypertensive rats.", International Journal of Pharmaceutical & Biological Archive, Volume 5, Number 1, 2014, pp. 103-109. 2014.
T.Rajeshwari, B Raja , "Antihypertensive antihyperlipidemic and antioxidantinfluence of D carvone in L NAME induced hypertensive rats.", International Journal of Pharmaceutical & Biological Archive, Volume 5, Number 4, 2014, pp. 82-88. 2014.
T.Dhanakshmi and B. Raja , "Antidiabetic and antihypertensive effect of dehydrozingerone in model of streptozotocin induced diabetic and nω- nitro-l arginine methyl ester hydrochloride (l-name) hypertensive rats.", International Journal of Current Research , Volume 6, Number 3, Mar 2014, pp. 5875-5882. 2014.
S Kumar, P Prahalathan, M Saravanakumar, B Raja , "Vanillic acid prevents the deregulation of lipid metabolism, endothelin 1 and up regulation of endothelial nitric oxide synthase in nitric oxide deficient hypertensive rats.", European journal of pharmacology , Volume 15, Number 743, Nov 2014, pp. 117-125. 10.1016/j.ejphar.2014.09.010.
T Silambarasan, J Manivannan, MK Priya, N Suganya, B Raja, S Chatterjee , "Sinapic Acid Prevents Hypertension and Cardiovascular Remodeling in Pharmacological Model of Nitric Oxide Inhibited Rats.", PloS one, Volume 9, Number 12, Dec 2014, pp. 1-20. 10.1371/journal.pone.0115682.
S Kumar, P Prahalathan, B Raja, "Vanillic acid: A potential inhibitor of cardiac and aortic wall remodeling in l-NAME induced hypertension through upregulation of endothelial nitric oxide synthase.", Environmental toxicology and pharmacology, Volume 38 (2), Number 2, 2014, pp. 643-652. 2014.
T Rajeshwari, B Raja, J Manivannan, T Silambarasan , "Valproic acid attenuates blood pressure, vascular remodeling and modulates ET-1 expression in L-NAME induced hypertensive rats. .", Biomedicine & Preventive Nutrition , Volume 4, Number 2, Apr 2014, pp. 195-202. 10.1016/j.bionut.2013.09.002.
Ramasamy T, Kannan K, Susanth V, Raja B, Santhosh Kumar Mishra, "Atorvastatin prevents sepsis-induced downregulation of myocardial β1-adrenoceptors and decreased camp response in mice.", Shock, Volume 41, Number 5, May 2014, pp. 406-412. 10.1097/SHK.0000000000000138.
S Sivakumar, CP Khatiwada, J Sivasubramanian, B Raja , "Protective effects of deferiprone and desferrioxamine in brain tissue of aluminum intoxicated mice: An FTIR study.", Biomedicine & Preventive Nutrition , Volume 4, Number 1, Jan 2014, pp. 53-61. 10.1016/j.bionut.2013.06.001.
S Sivakumar, CP Khatiwada, J Sivasubramanian, B Raja, "FTIR study of protective action of deferoxamine and deferiprone on the kidney tissues of aluminum loaded mice.", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 118, Number 1, Jan 2014, pp. 488-497. 2014/1/24.
Thiyagarajan Rajeshwari,Boobalan Raja,Jeganathan Manivannan, Thangarasu Silambarasan,Thanikkodi Dhanalakshmi, "Valproic acid prevents the deregulation of lipid metabolism and renal renin–angiotensin system in l-NAME induced nitric oxide deficient hypertensive rats.", Environmental toxicology and pharmacology, Volume 37, Number 3, 2014, pp. 936-945. DOI: 10.1016/j.etap.2014.02.008.
O Senthamizhselvan, J Manivannan, T Silambarasan, B Raja, "Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion.", European Journal of Pharmacology, Volume 736, Number 1, Aug 2014, pp. 131-137. doi: 10.1016/j.ejphar.2014.04.026.
J Manivannan, J Shanthakumar, P Arunagiri, B Raja, E Balamurugan, "Diosgenin interferes coronary vasoconstriction and inhibits osteochondrogenic transdifferentiation of aortic VSMC in CRF rats.", Biochimie, Volume 102, Number 1, Apr 2014, pp. 183-187. DOI: 10.1016/j.biochi.2014.03.011.
S Sivakumar, CP Khatiwada, J Sivasubramanian, B Raja, "FT-Raman study of deferoxamine and deferiprone exhibits potent amelioration of structural changes in the liver tissues of mice due to aluminum exposure.", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 118, Number 1, Jan 2014, pp. 461-469. 2014/1/24.
J Manivannan, TR Barathkumar, J Sivasubramanian, P Arunagiri, B Raja, E Balamurugan, "Diosgenin attenuates vascular calcification in chronic renal failure rats.", Molecular and cellular biochemistry, Volume 378, Number (1-2), 2013, pp. 9-18. 10.1007/s11010-013-1588-8.
J Manivannan, E Balamurugan, T Silambarasan, B Raja, "Diosgenin improves vascular function by increasing aortic eNOS expression, normalize dyslipidemia and ACE activity in chronic renal failure rats.", Molecular and cellular biochemistry, Volume 384, Number (1-2), Dec 2013, pp. 113-120. 1-12-2013.
S Sivakumar, J Sivasubramanian, J Manivannan, B Raja , "Aluminium induced metabolic changes in kidney and heart tissue of mice: a Fourier transform infrared spectroscopy study.", RSC Advances, Volume 3, Number 43, Nov 2013, pp. 20896-20904. 10.1039/c3ra42714e.
S Sivakumar, J Sivasubramanian, CP Khatiwada, J Manivannan, B Raja, "Determination of aluminium induced metabolic changes in mice liver: A Fourier transform infrared spectroscopy study.", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 110, Number 1, Jun 2013, pp. 241-248. 2013/6/30.
M Saravanakumar, B Raja, "Effect of Veratric Acid on the Cardiovascular Risk of L-NAME–induced Hypertensive Rats.", Journal of cardiovascular pharmacology, Volume 59, Number 6, Jun 2012, pp. 553-556. 2012/6/1.
S Kumar, M Saravanakumar, B Raja , "Antihypertensive, antioxidant and free radical scavenging potential of syringic and vanillic acid in L-NAME induced hypertension. In-vivo and in-vitro study.", Journal of Pharmacy Research , Volume 5, Number 5, Jan 2012, pp. 2942-2952. 2012.
P Prahalathan, S Kumar, B Raja, "Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate-salt hypertensive rats: a biochemical and histopathological evaluation.", Metabolism, Volume 61, Number 8, Aug 2012, pp. 1087-1099. 2012/8/31.
S Kumar, P Prahalathan, B Raja , "Syringic acid ameliorates L-NAME-induced hypertension by reducing oxidative stress.", Naunyn-Schmiedeberg's archives of pharmacology , Volume 385, Number 12, Dec 2012, pp. 1175-1184. 10.1007/s00210-012-0802-7.
P Prahalathan, S Kumar, B Raja , "Effect of morin, a flavonoid against DOCA-salt hypertensive rats: a dose dependent study.", Asian Pacific journal of tropical biomedicine , Volume 2, Number 6, Jun 2012, pp. 443-448. 10.1016/S2221-1691(12)60073-2.
M Saravanakumar, J Manivannan, J Sivasubramanian, T Silambarasan,, "Molecular metabolic fingerprinting approach to investigate the effects of borneol on metabolic alterations in the liver of nitric oxide deficient hypertensive rats.", Molecular and cellular biochemistry, Volume 362, Number 1-2, Mar 2012, pp. 203-209. 2012/3/1.
S Sivakumar, J Sivasubramanian, B Raja, "Aluminium induced structural, metabolic alterations and protective effects of desferrioxamine in the brain tissue of mice: An FTIR study.", Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, Volume 99, Number 1, Dec 2012, pp. 252-258. 2012/12/15.
B Raja, M Saravanakumar, G Sathya, "Veratric acid ameliorates hyperlipidemia and oxidative stress in Wistar rats fed an atherogenic diet.", Molecular and cellular biochemistry, Volume 366, Number (1-2), Jul 2012, pp. 21-30. 2012/7/1.
T Silambarasan, B Raja, "Diosmin, a bioflavonoid reverses alterations in blood pressure, nitric oxide, lipid peroxides and antioxidant status in DOCA-salt induced hypertensive rats.", European Journal of Pharmacology, Volume 679, Number 1, Mar 2012, pp. 81-89. 2012/3/15.
Subramanian Kumar, Pichavaram Prahalathan, Boobalan Raja, "Antihypertensive and antioxidant potential of vanillic acid, a phenolic compound in l-NAME-induced hypertensive rats: A dose-dependence study.", Redox Report, Volume 16, Number 5, Sep 2011, pp. 208-215. 2011.
M Saravanakumar, B Raja, "Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats.", European Journal of Pharmacology, Volume 671, Number 1, May 2011, pp. 87-94. 2011.
V Ramachandran, R Saravanan, B Raja , "Attenuation of oxidative stress by syringic acid on acetaminophen-induced nephrotoxic rats.", Comparative Clinical Pathology , Volume 21, Number 6, Dec 2011, pp. 1559-1564. 10.1007/s00580-011-1327-z.
S Kumar, M Saravana Kumar, B Raja , "Efficacy of piperine, an alkaloidal constituent of pepper on nitric oxide, antioxidants and lipid peroxidation markers in L-NAME induced hypertensive rats.", International Journal of Research in Pharmaceutical Sciences , Volume 1, Number 3, Jan 2010, pp. 300-307. 2010.
V Ramachandran, SJD Mol, B Raja , "Combined effects of vanillic and syringic acids on hepatic markers, lipid peroxides and antioxidants in acetaminophen induced hepatotoxicity in wistar rats: biochemical and histopathological evidences.", Pharmacologyonline, Volume 2, Number 1, Jan 2010, pp. 475-486. 2010.
V Ramachandran, B Raja , "Protective effects of syringic acid against acetaminophen-induced hepatic damage in albino rats.", Journal of basic and clinical physiology and pharmacology, Volume 21, Number 4, 2010, pp. 369-386. 10.1515/jbcpp.2010.21.4.369.
M.Saravanakumar,S Kumar, B Raja , "Antihyperlipidemic effect of borneol on L-NAME induced hypertensive rats.", Journal of Pharmacy Research , Volume 3, Number 10, 2010, pp. 2362-2365. 2010.
B Raja, J Manivannan , "Evaluation of in vitro antioxidant and antimicrobial potential of methanolic leaf extract of Anisomeles malabarica (Linn.).", Journal of Pharmacy Research , Volume 3, Number 7, 2010, pp. 1471-1474. 2010.
M.Saravana Kumar, S.Kumar, B.Raja , "Antihypertensive and antioxidant potential of borneol-a natural terpene in L-NAMEâ,“induced hypertensive rats.", International Journal of Pharmaceutical & Biological Archive, Volume 1, Number 3, 2010, pp. 271-279. 2010.
B Raja, SD Mol , "The protective role of vanillic acid against acetaminophen induced hepatotoxicity in rats.", Journal of Pharmacy Research, Volume 3, Number 7, 2010, pp. 1480-1484. 2010.
B Raja, KV Pugalendi, MM Arjunan , "Aqueous extract of Melothria maderaspatana (Linn.) leaf exerts antihypertensive effect and improves MUFA, PUFA and membrane fluidity of erythrocytes in patients with hypertension-an electron paramagnetic resonance investigation.", J Herbal Med Toxicol , Volume 4, Number 1, 2010, pp. 133-139. 2010.
B Raja, K Pugalendi , "Evaluation of antioxidant activity of Melothria maderaspatana in vitro.", Central European Journal of Biology, Volume 5, Number 2, Jan 2010, pp. 224-230. 10.2478/s1535-010-0005-5.
Boobalan Raja, Kuppusamy Kaviarasan, Mangalam Muthu Arjunan, and Kodukkur Viswanathan Pugalendi., "Effect of Melothria maderaspatana Leaf-Tea Consumption on Blood Pressure, Lipid Profile, Anthropometry, Fibrinogen, Bilirubin, and Albumin Levels in Patients with Hypertension .", The Journal of Alternative and Complementary Medicine, Volume 13, Number 3, May 2007, pp. 349-354. 2007.
B Raja, K Kaviarasan, MM Arjunan, KV Pugalendi , "Melothria maderaspatana leaf extract for treating hypertension: Chemistry and effects on biomarkers.", Alternative & Complementary Therapies , Volume 11, Number 5, Oct 2005, pp. 264-268. 10.1089/act.2005.11.264.
P Prahalathan, M Saravanakumar, B Raja, "The flavonoid morin restores blood pressure and lipid metabolism in DOCA-salt hypertensive rats.", Redox Report , Volume 17, Number 4, Jul 2002, pp. 167-175. 2012.
List of Conferences - National
B.Raja, Proteomics in experimental Hypertension, National conference on drug discovery and translational medicine, Mar 14-16, 2019, Annamalai University, pp. 22-22. Chidambaram, Rasi Printers.
List of Conferences - International
B.Raja T.Silambarasan, J.Manivannan, Translational Pre-clinical studies identified novel dietary cardioprotective nutraceuticals, International Conference on Cardiovascular Translational Research, Jan 22-25, 2016, IIT Madras, Chennai, pp. 29-29. IIT Madras, Journal of the Practice of Cardiovascular Sciences.
B.Raja, HDAC inhibition improves dyslipidemia, International Symposium on Histone deacetylases as therapeutic targets, Oct 13-13, 2014, Kyungpook National University School of Medicine, South Korea, pp. 55-55. Kyungpook National University School of Medicine, Kyungpook National University School of Medicine.
List of Book Published
Raja B and Thangaraj M, Workshop manuel on Genomics, proteomics and Bioinformatics, Nagerkoil, Tamil Nadu: Hari Krish Publication, 978-93-80819-11-2, pp. 1-72. Jul 2013.
Raja B and Thangaraj M, Food and brain Health, Nova Science Publishers, Inc. 400 Oser Ave Suite 1600 Hauppauge NY 11788-3619 United States of America Ph: (631)231-7269 Fax: (631)231-8175 Email: nova.main@novapublishers.com: Nova Science Publishers, 978-1-63117-738-5, pp. 301-326. Aug 2014, https://www.novapublishers.com/catalog/product-info.php?products-id=49255.
Thangaraj M and Raja B, Food and Brain Health, Nova Science Publishers, Inc. 400 Oser Ave Suite 1600 Hauppauge NY 11788-3619 United States of America Ph: (631)231-7269 Fax: (631)231-8175 Email: nova.main@novapublishers.com: Nova Science Publishers, 978-1-63117-738-5, pp. 203-220. Aug 2014, https://www.novapublishers.com/catalog/product-info.php?products-id=49255.
List of Awards /Honours / Memberships
International Society of Hypertension - 16462
Society of Biological Chemists, Annamalainagar Chapter - 2016